I recently moved a washing machine connection, and had to deal with 2x4 walls. I had to run the pipe through several studs, and it appeared to be load bearing so I didn't want to take any chances at all. Reframing the wall was out of the question for this projects scope, and that would have also destroyed a wall in the bathroom on the other side.
What I ended up doing was basically building another 2x4 wall in front of the existing wall and ran the pipes through those "studs". That wall was not structural whatsoever, so I didn't worry about the large holes. I was able to attach the new 2x4s to the old ones in several places.
Because of the large holes in the 2x4s, I did use nail protector plates over each hole to avoid accidents when the new drywall was hung.
1x2's are typically very low quality and I wouldn't trust them to add any stiffness to the wall. On a non-load bearing wall you might be able to get away with adding 2x2s, but I'm not even sure if I would do that. A 2" PVC pipe requires a 2 3/8" hole (I think?) and that is a shockingly big chunk of the 2x4 once you see it in person. I thought it would be better looking at it on paper, but its a very large hole.