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Assuming ordinary loads on the floor and etc. you can look this up on a span table, such as this one. This shows that for a 16' span, 2x10's spaced 12" on center are adequate even with the Eastern spruce number for a 40#/ft-ft live load. You could get by with 2x8's if you use #1 grade yellow pine and only need to support a 30#/ft-ft live load, but ...

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