Take this pattern for example, the three pieces circled there won't align at the edges if you want to maintain the same gap between the tiles/pavers.
For he horizontal 6x12 the width is 12 +2x1/4 gaps at each end =12.5"
The two pieces below it have three gaps there so the width is 6+6+3x1/4=12.75"
What am I missing ?