There's been some discussion on this board about the NEC 2020 requirement for GFCI on 240V ("250V") outlets. I assume houses built prior to that new rule won't need to be retrofitted. Is GFCI required when adding a new 240V outlet in the garage? Years down the road, what are the chances an inspector will flag it to potential buyers?
Not grandfathered. GFCI required for receptacles. 100% chance of being caught. The date for NEC compliance purposes is the date on the permit. Unpermitted work has no permit, so its date is the future.
Hard-wired 240V loads don't need GFCI protection.
If this is for electric vehicle charging, you are falling into a very common novice mistake. EVSEs should not be on GFCI, because they have a much superior GFCI of their own.
The little "fits in a shoebox" EVSE that comes with the car is intended to live in the trunk and be used for opportunity charging on the road. It should not be your primary EVSE.