I recently replace a flush valve seal:
I noticed the old one had a quarter inch "bump" on - I had no idea how that would have happened, but to me seemed to explain why the seal was not sealing:
Even more recently, I had a second toilet that was intermittently running on its own. I replaced that seal, and the same bump was there on that seal! The replacement valve seals do not have any bumps (as I would expect). Is this bump expected on some seals? Or does this happen over time for some reason?