Sealed combustion is your friend
Just about all power vented gas appliances can be configured as sealed combustion appliances, where they draw their combustion air directly from outside via a 2nd pipe instead of pulling it in from the room. This means that no matter what happens, as long as the vent integrity is good, they can't backdraft any atmospheric vented appliances that happen to be sharing the same room, nor will they have issues with starving for combustion air if the house is sealed up tight.
But...you need to use the right stuff when venting
The one caveat with most power-vented appliances is that the corrosive conditions inside the vent piping (due to the possible presence of liquid condensate from combustion moisture), along with the need to provide proper sealing to prevent combustion exhaust leakage, prevent the use of standard B-vent for venting them. While the appliance manufacturers generally specify the use of PVC pipe as a vent material as it's cheap and easy to get, PVC is actually the wrong stuff to use for venting appliance exhaust, as it's just not rated for a high enough temperature to survive if stack temperatures rise much due to impaired appliance operation, such as if a water heater has a scaled-up heat exchanger or if a furnace filter is in need of changing. In fact, there have been documented close calls, and a reported multi-fatality CO mishap, that were due to the use of PVC venting for condensing gas appliances.
The correct (albeit expensive) thing to use in this case is a UL 1738 rated Special Gas Vent, suitable for Category IV gas appliances. These are made from stainless steel, and thus provide both the necessary heat resistance and the necessary corrosion resistance for this application. While they are proprietary systems, and cannot be mixed, most manufacturers of Special Gas Vent provide comprehensive selections of fittings and sizes, and extensively warrant their systems against premature failure when professionally installed, up to and including some manufacturers offering limited lifetime warranties on their stainless steel special gas vent systems.