I have a GFCI outlet in my powder room that needs to be replaced. Is it significantly more difficult to replace a GFCI than an ordinary outlet?
No, but you do need to identify the "line" (supply) and "load" (additionally-protected portion of the circuit, i.e. downstream outlets) cables. If they're connected to the wrong terminals the downstream section of the circuit won't be protected.
With a standard outlet, connection location isn't important other than maintaining polarity.
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For example, in our tract house both bathrooms are on one circuit and were protected by a single GFCI receptacle installed in one bathroom, the one closer to the electric panel. In that case I used the "load" connection to go to the farther bathroom. The deficiency in this arrangement is that if there would be a GF trip (we never had one) due to activity in the farther bathroom someone would have to go to the first bathroom to reset the GFCI receptacle. For some reason I later took out the GFCI receptacle and put in a GFCI breaker. A trip now would mean someone going to the garage. – Jim Stewart Jul 31 '18 at 21:29
LOADterminals have warning tape on them saying "Do not use - for wizards only" - not exactly, but that's what it means. If you heed that advice, super easy. If you want to play "Sorcerer's Apprentice", fairly hard and easy to botch. – Harper - Reinstate Monica Aug 1 '18 at 5:47