Extra deep U-channel affixed more or less rigidly to the vent and beam, with the dry wall free floating in the channel. Use a forklift to install it, a big fork lift. Don't let Don't create a paint-seal form between the drywall and the U-channel or it'll look uglier than whatever when it shifts over time, so cut in with at least a coat of primer on the dry wall before you hangassembly.
You will likely need a forklift for this project, likely a big fork lift.