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How do I design a home air filtration system?

I live in a city with bad air pollution and no central HVAC system. I have two air purifiers and an air quality monitor. Both air purifiers are effective in reducing the particulate matter count. But ...
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Can I clean indoor HEPA filters with an acid wash? Hydrogen peroxide?

I have two HEPA filters in my house that are at least 5 years old. I clean them regularly (take them outside with a respirator on and blow them out with an air compressor), but I'm concerned that ...